Safety and efficacy of leflunomide and infliximab versus methotrexate and infliximab combination therapy in rheumatoid arthritis.

نویسندگان

  • T Cobo Ibáñez
  • M Yehia Tayel
  • A Balsa Criado
  • A Hernández Sanz
  • E Martín Mola
چکیده

1. Bodolay E, Szekanecz Z, Dévényi K et al. Evaluation of interstitial lung disease in mixed connective tissue disease (MCTD). Rheumatology 2005;44:655–61. 2. Sharp GC, Irvin WS, Tan EM et al. Mixed connective tissue disease – an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med 1972;52:148–59. 3. Winn DM, Wolfe JF, Lindberg DA et al. Identification of a clinical subset of systemic lupus erythematosus by antibodies to SM antigen. Arthritis Rheum 1979;22:1334–7. 4. Amigues JM, Cantagrel A, Abbal M et al. Comparative study of 4 diagnosis criteria sets for mixed connective tissue disease in patients with anti-RNP antibodies. J Rheumatol 1996;23:2055–62. 5. Hoffman RW, Greidinger EL. Mixed connective tissue disease. Curr Opin Rheumatol 2000;12:386–90.

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The influence of previous and concomitant leflunomide on the efficacy and safety of infliximab therapy in patients with rheumatoid arthritis; a longitudinal observational study.

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Combination therapy of the chimeric monoclonal anti-tumor necrosis factor alpha antibody (infliximab) with methotrexate in patients with rheumatoid arthritis.

Infliximab, a chimeric anti-TNF alpha antibody, showed in two double-blind placebo-controlled trials efficacy in combination with methotrexate (MTX) in patients with severe rheumatoid arthritis (RA). Whereas in the first trial low-dose MTX or placebo was compared to infliximab alone and in combination, the second trial compared infliximab to placebo in patients with active RA despite maximal to...

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Rheumatoid Arthritis: Refractory to Infliximab, a Tumor Necrosis Factor Inhibitor

UNLABELLED Rheumatoid arthritis is one of the commonest autoimmune diseases. It is a chronic, progressive, systemic inflammatory disorder affecting the synovial joints and typically producing symmetrical arthritis. If left untreated, it leads to joint destruction and thus deformity and disability.In the recent years, advances in molecular biology have led to a variety of new treatment approache...

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عنوان ژورنال:
  • Rheumatology

دوره 44 11  شماره 

صفحات  -

تاریخ انتشار 2005